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Institute for Mathematical Sciences

Computational Approaches to the Analysis of Biomolecular Sequences, Structures and Their Functions and Applications to Biotechnology and Clinical Data Studies

(23 - 27 Mar 2020)

Venue: IMS Auditorium
PDF Abstracts

Monday, 23 Mar 2020

09:00am - 09:30amRegistration
09:30amChair: Frank Eisenhaber, Bioinformatics Institute (BII) - A*Star, Singapore
09:30am - 09:50amWelcome by Organizers
09:50am - 10:30am

About the limited potential, yet instrumental role of computational biology and the target identification bottleneck due to the decline in biomolecular mechanism discovery after 2000

(Video)



Frank Eisenhaber
Bioinformatics Institute - A*Star, Singapore
10:30am - 11:00amGroup Photo & Coffee Break
11:00am - 11:45am

Antibody engineering, scientific phone apps, viral research, and device prototyping in APD lab



Samuel Gan
Bioinformatics Institute - A*Star, Singapore
11:45am - 12:00pm

A holistic view of proteins: impact on antibody engineering and drug discovery



Chinh Tran-To Su
Bioinformatics Institute - A*Star, Singapore
12:00pm - 01:15pmLunch Reception at IMS
01:15pm - 01:30pmRegistration
01:30pmChair: Frank Eisenhaber, Bioinformatics Institute (BII) - A*Star, Singapore
01:30pm - 02:00pm

Deriving structure profiles corresponding to functional loops in proteins

(Video)



Melvin Yin
Bioinformatics Institute - A*Star, Singapore
02:00pm - 02:30pm

Discovery of an antifungal compound BII-Rafflesfungin: a computational perspective



Swati Sinha
Bioinformatics Institute - A*Star, Singapore
02:30pm - 03:00pmCoffee Break
03:00pm - 04:00pm

Evolutionary lessons learned from transcriptome data

(Video)



Marek Mutwil
Nanyang Technological University, Singapore

Tuesday, 24 Mar 2020

09:00am - 09:30amRegistration
09:30amChair: Igor N. Berezovsky, Bioinformatics Institute (BII) - A*Star, Singapore
09:30am - 10:30am

Abeta chaperones in Alzheimer's disease: friends or foes?

(Video)



Konstantin Pervushin
Nanyang Technological University, Singapore
10:30am - 11:00amCoffee Break
11:00am - 12:00pm

Tutorial:

Modeling allostery: global protein structural changes in response to local perturbations

(Video)



Zhen Wah Tan
Bioinformatics Institute - A*Star, Singapore
12:00pm - 01:15pmLunch Reception at IMS
01:15pm - 01:30pmRegistration
01:30pmChair: Igor N. Berezovsky, Bioinformatics Institute (BII) - A*Star, Singapore
01:30pm - 02:30pm

3D genome: from organization to function



Amartya Sanyal
Nanyang Technological University, Singapore
02:30pm - 03:00pmCoffee Break
03:00pm - 04:00pm

Tutorial:

Capturing communities in diffusive chromatin polymers via Markov state modeling and transition path theory

(Video)



Zhen Wah Tan
Bioinformatics Institute - A*Star, Singapore

Wednesday, 25 Mar 2020

09:30amResearch and Discussion

Thursday, 26 Mar 2020

11:00amChair: Lars Nordenskiöld, Nanyang Technological University, Singapore
11:00am - 12:00pm

Multiscale modelling approaches to large systems in biology: understanding infectious diseases and the host response

(Video)



Peter J. Bond
Bioinformatics Institute - A*Star, Singapore
12:00pm - 01:30pmLunch Break
01:30pmChair: Lars Nordenskiöld, Nanyang Technological University, Singapore
01:30pm - 02:30pm

Multiscale modeling of macromolecular systems by structure-based coarse-graining

(Video)



Alexander Lyubartsev
Stockholm University, Sweden
02:30pm - 03:00pmCoffee Break
03:00pmChair: Igor N. Berezovsky, Bioinformatics Institute (BII) - A*Star, Singapore
03:00pm - 04:00pm

Whole viral particle metastability and dynamics by HDX mass spectrometry

(Video)



Ganesh Srinivasan Anand
National University of Singapore, Singapore
04:00pm - 04:15pm

To bind or not to bind: IgM versus IgG in Pertuzumab and Trastuzumab



Firdaus Samsudin
Bioinformatics Institute - A*Star, Singapore

Friday, 27 Mar 2020

09:30amChair: Frank Eisenhaber, Bioinformatics Institute (BII) - A*Star, Singapore
09:30am - 10:30am

Amino acid sequence insertions or deletions inside Mycobacterium tuberculosis’s respiratory complexes provide fitness for the pathogen and new pathways for TB-drug development



Gerhard Grüber
Nanyang Technological University, Singapore
10:30am - 11:00amCoffee Break
11:00am - 12:00pm

A genome assembly quality assessment measure that integrates contiguity, completeness, and correctness



Lim Soon Wong
National University of Singapore, Singapore
12:00pm - 01:30pmLunch Break
01:30pmChair: Igor N. Berezovsky, Bioinformatics Institute (BII) - A*Star, Singapore
01:30pm - 02:30pm

Tutorial:

Reinforcement learning and its biomedical applications

(Video)



Mahsa Paknezhad
Bioinformatics Institute - A*Star, Singapore
02:30pm - 03:00pmCoffee Break
03:00pm - 04:00pm

Tutorial:

Computational imaging with deep learning: biomedical focus

(Video)



Kaicheng Liang
Bioinformatics Institute - A*Star, Singapore
04:00pm - 04:15pm

Sequence similarity networks: a working model for defining the 'known-unknowns' of gene function in microbiomes



Rohan Williams
National University of Singapore, Singapore