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Institute for Mathematical Sciences

Computational Approaches to the Analysis of Biomolecular Sequences, Structures and Their Functions and Applications to Biotechnology and Clinical Data Studies

(23 - 27 Mar 2020)

Venue: IMS Auditorium
PDF Abstracts

Monday, 23 Mar 2020

09:00am - 09:30amRegistration
09:30amChair: Frank Eisenhaber, Bioinformatics Institute (BII) - A*Star, Singapore
09:30am - 09:50amWelcome by Organizers
09:50am - 10:30am

About the limited potential, yet instrumental role of computational biology and the target identification bottleneck due to the decline in biomolecular mechanism discovery after 2000



Frank Eisenhaber
Bioinformatics Institute - A*Star, Singapore
10:30am - 11:00amGroup Photo & Coffee Break
11:00am - 11:45am

Antibody engineering, scientific phone apps, viral research, and device prototyping in APD lab



Samuel Gan
Bioinformatics Institute - A*Star, Singapore
11:45am - 12:00pm

A holistic view of proteins: impact on antibody engineering and drug discovery



Chinh Tran-To Su
Bioinformatics Institute - A*Star, Singapore
12:00pm - 01:15pmLunch Reception at IMS
01:15pm - 01:30pmRegistration
01:30pmChair: Frank Eisenhaber, Bioinformatics Institute (BII) - A*Star, Singapore
01:30pm - 02:00pm

Deriving structure profiles corresponding to functional loops in proteins



Melvin Yin
Bioinformatics Institute - A*Star, Singapore
02:00pm - 02:30pm

Discovery of an antifungal compound BII-Rafflesfungin: a computational perspective



Swati Sinha
Bioinformatics Institute - A*Star, Singapore
02:30pm - 03:00pmCoffee Break
03:00pm - 04:00pm

Evolutionary lessons learned from transcriptome data



Marek Mutwil
Nanyang Technological University, Singapore

Tuesday, 24 Mar 2020

09:00am - 09:30amRegistration
09:30amChair: Igor N. Berezovsky, Bioinformatics Institute (BII) - A*Star, Singapore
09:30am - 10:30am

Abeta chaperones in Alzheimer's disease: friends or foes?



Konstantin Pervushin
Nanyang Technological University, Singapore
10:30am - 11:00amCoffee Break
11:00am - 12:00pm

Tutorial:

Modeling allostery: global protein structural changes in response to local perturbations



Zhen Wah Tan
Bioinformatics Institute - A*Star, Singapore
12:00pm - 01:15pmLunch Reception at IMS
01:15pm - 01:30pmRegistration
01:30pmChair: Igor N. Berezovsky, Bioinformatics Institute (BII) - A*Star, Singapore
01:30pm - 02:30pm

3D genome: from organization to function



Amartya Sanyal
Nanyang Technological University, Singapore
02:30pm - 03:00pmCoffee Break
03:00pm - 04:00pm

Tutorial:

Capturing communities in diffusive chromatin polymers via Markov state modeling and transition path theory



Zhen Wah Tan
Bioinformatics Institute - A*Star, Singapore

Wednesday, 25 Mar 2020

09:30amResearch and Discussion

Thursday, 26 Mar 2020

11:00amChair: Lars Nordenskiöld, Nanyang Technological University, Singapore
11:00am - 12:00pm

Multiscale modelling approaches to large systems in biology: understanding infectious diseases and the host response



Peter J. Bond
Bioinformatics Institute - A*Star, Singapore
12:00pm - 01:30pmLunch Break
01:30pmChair: Lars Nordenskiöld, Nanyang Technological University, Singapore
01:30pm - 02:30pm

Multiscale modeling of macromolecular systems by structure-based coarse-graining



Alexander Lyubartsev
Stockholm University, Sweden
02:30pm - 03:00pmCoffee Break
03:00pmChair: Igor N. Berezovsky, Bioinformatics Institute (BII) - A*Star, Singapore
03:00pm - 04:00pm

Whole viral particle metastability and dynamics by HDX mass spectrometry



Ganesh Srinivasan Anand
National University of Singapore, Singapore
04:00pm - 04:15pm

To bind or not to bind: IgM versus IgG in Pertuzumab and Trastuzumab



Firdaus Samsudin
Bioinformatics Institute - A*Star, Singapore

Friday, 27 Mar 2020

09:30amChair: Frank Eisenhaber, Bioinformatics Institute (BII) - A*Star, Singapore
09:30am - 10:30am

Amino acid sequence insertions or deletions inside Mycobacterium tuberculosis’s respiratory complexes provide fitness for the pathogen and new pathways for TB-drug development



Gerhard Grüber
Nanyang Technological University, Singapore
10:30am - 11:00amCoffee Break
11:00am - 12:00pm

A genome assembly quality assessment measure that integrates contiguity, completeness, and correctness



Lim Soon Wong
National University of Singapore, Singapore
12:00pm - 01:30pmLunch Break
01:30pmChair: Igor N. Berezovsky, Bioinformatics Institute (BII) - A*Star, Singapore
01:30pm - 02:30pm

Tutorial:

Reinforcement learning and its biomedical applications



Mahsa Paknezhad
Bioinformatics Institute - A*Star, Singapore
02:30pm - 03:00pmCoffee Break
03:00pm - 04:00pm

Tutorial:

Computational imaging with deep learning: biomedical focus



Kaicheng Liang
Bioinformatics Institute - A*Star, Singapore
04:00pm - 04:15pm

Sequence similarity networks: a working model for defining the 'known-unknowns' of gene function in microbiomes



Rohan Williams
National University of Singapore, Singapore